Best Evidence Review of Multivitamins in the Prevention of Cancer
Gaziano JM, Sesso HD, Christen WG, et al. Multivitamins in the prevention of cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA. 2012;308:1871-1880.
The Physicians’ Health Study (PHS) II was the first large-scale, randomized, placebo-controlled trial to test the long-term effects of a daily multivitamin on the prevention of cancer. The results — an 8% decrease in total cancer incidence among men taking a daily multivitamin — have generated significant attention in the popular press. But is the evidence strong enough to recommend a change in clinical practice? How should physicians best use the results of this study?